ghrelin does not modulate angiogenesis in matrigel plug in normal and diet-induced obese mice
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Ghrelin does not modulate angiogenesis in matrigel plug in normal and diet-induced obese mice
BACKGROUND The reciprocal interaction between adipocytes and angiogenesis is considered as an essential component in the development and expansion of adipose tissue. The aim of this study was to evaluate the effect of ghrelin on angiogenic response using in vivo angiogenesis assay of matrigel plug and its correlation with serum leptin levels in normal and diet-induced obese mice. MATERIALS AN...
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Objective(s): Atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. Ghrelin has several modulatory effects on cardiovascular system. In this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese and control mice. Materials and Methods:This study was conducted on 24 male C...
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BACKGROUND Ghrelin is a novel growth hormone releasing peptide that mainly regulates food intake and energy homeostasis, however, recently, it is indicated that it may be closely related with physiological and/or pathological angiogenesis. OBJECTIVES The objective of the present study was to evaluate the effect of systemic ghrelin administration on angiogenesis in hindlimb ischemia in normal ...
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Introduction. Ghrelin is a gastrointestinal endocrine peptide that was initially identified as the endogenous ligand of growth hormone secretagogue receptor; however, recently, the cardiovascular effect of this peptide has been indicated. In this study, we investigated the effect of ghrelin administration on serum biomarkers of angiogenesis including leptin, nitric oxide (NO), vascular endothel...
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OBJECTIVE Ghrelin, a stomach-derived, secreted peptide, and its receptor (growth hormone secretagogue receptor, GHSR) are known to modulate food intake and energy homeostasis. The ghrelin system is also expressed broadly in cardiovascular tissues. Since ghrelin has been associated with anti-inflammatory and anti-atherogenic properties, but is also well known to promote obesity and impair glucos...
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objective(s): atherosclerosis is a chronic immune-inflammatory disease that generally leads to ischemic heart disease. ghrelin has several modulatory effects on cardiovascular system. in this study, we investigated the effect of ghrelin on aortic intima-media thickness, size and the number of adipocyte cells in obese and control mice. materials and methods:this study was conducted on 24 male c5...
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عنوان ژورنال:
journal of research in medical sciencesجلد ۱۸، شماره ۱۱، صفحات ۰-۰
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